Vacancy expired!
Software Guidance & Assistance, Inc., (SGA), is searching for a
Scientist for a CONTRACT assignment with one of our premier Pharmaceutical Services clients in South San Francisco, CA. Responsibilities :- Support Fab, antibody, antibody-drug conjugate (ADC) and other complex biotherapeutic projects in research and development through implementation of MHC-associated peptide proteomics workflow for immunogenicity risk assessment.
- Explore immuno-capture and mass spectrometry-based methods to support immunogenicity risk assessment of various biotherapeutics in preclinical and clinical development.
- Collaboratively develop and execute mass spectrometry-based proteomic workflows including sample preparation, LC-MS data acquisition, and novel data analysis approaches.
- Preparation of samples for immunopeptidomics profiling and protein quantification from primary cells, which will involve the isolation of immune cells from whole blood, and the culture of in vitro human cell lines
- Be involved in non-GLP sample analysis and data reporting.
- Work independently and in collaboration with colleagues within BAS/ADT and across various functional areas. The candidate may also
- Be involved in evaluating and exploring innovative technologies.
- A BS or MS degree in Analytical Chemistry, Biochemistry, Biological Sciences or a related scientific discipline with 4+ years industry experience in pharmaceutical or biotechnology drug development.
- In-depth knowledge and demonstrated proficiency in HPLC and mass spectrometry with a proven track record of solving bioanalytical problems.
- Expertise in bioanalysis of therapeutic peptides/proteins or proteomics is required, with specific hands-on experience using QTRAP 6500/7500 and/or Orbitrap MS technologies as a plus.
- Knowledge in immunoaffinity capture, proteolytic digestion/inhibition, and peptide analysis is a plus.
- Have experience or are interested in gaining experience working with primary immune cells and cancer cell lines is required (eg. PBMC isolation from whole blood, cellular phenotyping, cell activation and differentiation and antigen processing)
- Experience in LC-MS/MS qualitative and/or quantitative method development is required.
- Data analysis experience using different proteomic software including Proteome Discoverer, PMI or PEAKs is desirable.
- A motivated team player with strong communication and interpersonal skills is essential.
Vacancy expired!