Vacancy expired!
Job Description
The successful candidate will lead analytical assay support for the mRNA therapeutic Process Development group based in Chesterfield, MO.
This group is responsible for developing robust processes for the generation of RNA therapeutics. These RNA molecules are chosen by the vaccine research unit as candidates for the treatment in multiple therapeutic areas. The processes developed by the mRNA process development group are used in GMP manufacturing facilities to produce the RNA in large quantities for clinical and commercial needs.
The RNA production process involves in-vitro transcription of plasmid DNA, purification and filtration. Characterization of in-process samples are required in developing, scaling and optimizing the RNA manufacturing processes. The successful candidate will drive the analytical support to the team by performing analytical testing on in-process samples.
Job Responsibilities and Requirements:The successful candidate will drive analytical support efforts for the GTx process development group – receiving and managing samples, performing required analytical tests, processing the data and providing data summaries back to the responsible scientists.
Applicant would be providing in-process analytical support as part of an mRNA therapeutic process development team. The candidate should be skilled in analyzing low concentration, large biomolecules (ideally RNA and DNA) with specific training in HPLC, Gel Electrophoresis, Capillary gel electrophoresis (CGE). Familiarity with Agilent HPLC instruments (Both Empower and Open Lab software) preferred. Experience with mRNA handling technique, other analytical techniques (rheometry, SEC-MALS, DLS, qPCR, ddPCR), and the use of automatic liquid handlers for analytical sample prep and the use of data analysis software (Excel, Spotfire) would also be beneficial.
General requirements include performing data analysis using Microsoft Excel, composing scientific documents for electronic lab notebooks, and maintenance of experimental data in relevant electronic databases. Strong organizational skills and a readiness to support a safe working environment are also required.
Qualifications
- Bachelors or Masters Degree in Biotechnology, Biochemical Engineering, Analytical Chemistry, Chemical Engineering or other related fields.
- 3-5 years of relevant industrial experience
Additional Information
Position is full-time, M-F 8a.m.-5p.m., with overtime as needed. Candidates currently living in a commutable distance toChesterfield, MO are encouraged to apply.
What we Offer:Excellent full time benefits including comprehensive medical coverage, dental, and vision options
Life and disability insurance
401(k) with company match
Paid vacation and holidays
Vacancy expired!